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13 Hours Ago, Thomas from

Chillicothe,Ohio

Bought: Sildenafil (Cenforce)

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Tadalafil Oral Jelly
Apcalis Oral Jelly

  • Tadalafil Oral Jelly
  • ED033
  • In Stock

Premium High Quality Product & Original Active Substance!

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   Manufacturer's Suggested Retail Price (MSRP) per sachet is $9.03 ! Buying from us will save you at least 45.29%

Package per sachet Price SAVINGS BONUS Order
20mg/5g * 7 sachets
$4.94 $34.58 $0.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
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►Next orders 10% discount
20mg/5g * 14 sachets
$4.63 $64.82 $4.34
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
20mg/5g * 21 sachets
$3.96 $83.16 $20.58
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
20mg/5g * 28 sachets
$3.71 $103.88 $34.44
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
20mg/5g * 35 sachets
$3.51 $122.85 $50.05
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
20mg/5g * 42 sachets
$3.31 $139.02 $68.46
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
20mg/5g * 49 sachets
$3.22 $157.78 $84.28
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount

Tadalafil is an orally administered drug used to treat male erectile dysfunction (impotence). It is marketed worldwide under the brand name Cialis. It is a phosphodiesterase 5 (PDE5) inhibitor.

Tadalafil's distinguishing pharmacologic feature is its longer half-life (17.5 hours) compared with Viagra and Levitra (4-5 hours). This longer half-life results in a longer duration of action and is, in part, responsible for the Cialis nickname of the "weekend pill." This longer half-life also is the basis of current investigation for tadalafil's use in pulmonary arterial hypertension as a once-daily therapy.

Tadalafil tablets are indicated for the treatment of: erectile dysfunction (ED), the signs and symptoms of benign prostatic hyperplasia (BPH), the signs and symptoms of BPH (ED/BPH).

Apcalis-sx Oral Jelly is a gel form of tadalafil, absorbed much faster than tablet form. This is due to the fact that in the gel it is already in the form of a dispersion, the absorption of which into the systemic circulation begins already in the oral cavity. Has a pleasant fruity taste and is packaged in sealed bags that are convenient to carry in your pocket. The gel can be diluted with water or any soft drink or taken in its pure form, squeezing the contents of the sachet into the mouth. Apcalis-sx Oral Jelly in the form of jelly acts not only quickly (already 10 to 15 minutes after ingestion) and prolonged (up to 36 to 48 hours), but also milder than Viagra (sildenafil), with a minimal risk of side effects.

Tadalafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum.

This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Tadalafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum.

This means that, with tadalafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, tadalafil should not cause an erection.

Tadalafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle.

This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by tadalafil enhances erectile function by increasing the amount of cGMP.

Metabolism: Tadalafil is predominantly metabolized by CYP3A4 to a catechol metabolite. The catechol metabolite undergoes extensive methylation and glucuronidation to form the methylcatechol and methylcatechol glucuronide conjugate, respectively. In vitro data suggests the metabolites are not expected to be pharmacologically active at observed metabolite concentrations.

Absorption: After single oral-dose administration, the maximum observed plasma concentration (Cmax) of tadalafil is achieved between 30 minutes and 6 hours (median time of 2 hours). Absolute bioavailability of tadalafil following oral dosing has not been determined.

Route of elimination: Tadalafil is excreted predominantly as metabolites, mainly in the feces (approximately 61% of the dose) and to a lesser extent in the urine (approximately 36% of the dose).

Half life: 17.5 hours

All medicines may cause side effects, but many people have no, or minor, side effects.Some medical conditions may interact with Tadalafil.

Tell your doctor or pharmacist if you have any medical conditions.

Common tadalafil side effects may include: headache, flushing (warmth, redness, or tingly feeling), nausea, upset stomach, stuffy nose; or muscle pain, back pain, pain in your arms or legs.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Dale
17/Jan/2024

I am 49 years old I have been taking Tadalafil under various formats for last 4 years and it was given me rock rock hard erection 95% of the time after Tadalafil my life very Colorful and very enjoyable. I'm very confident in front of my girlfriend 25.

Edgar
05/Jan/2024

After my divorce, I liked to catch up what I've missed...if you know what I mean... every week number of new partners, but hey 55 y/o already and found there's lots of truth in the old saying 'use it or lose it'. First couple of sexual encounters not good. Apcalis Oral Jelly - some of my GF told me about it and referred me to RxMedWorld's website and I can say this stuff's awesome. I get enabling stronger and longer erections typically over 2 days before weakening. No apparent side effects unless some lower back muscle discomfort...it's just great - stud again.

Tomas
27/Dec/2023

At 69 the hormones do not deliver the same stimulation to get started and unless there is continuous action, my erection can fade. Apcalis Oral Jelly does a great job of overcoming both of these and gives results for about 2 days. Been using it for about 2 years now.

Marian
23/Dec/2023

This medicine works guys. I am doing daily dose of 20mg sachet. If this keeps up the cost will be very reasonable for the benefit received.

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